| Wk | Date | Opponent | TV |
| 1 | Sunday, Sept. 09, 2018 – 2:25 PM MST | Seattle Seahawks | FOX |
| 2 | Sunday, Sept. 16, 2018 – 2:25 PM MST | Oakland Raiders | CBS |
| 3 | Sunday, Sept. 23, 2018 – 11:00 AM MST | @ Baltimore Ravens | CBS |
| 4 | Monday, Oct. 1, 2018 – 6:15 PM MST | Kansas City Chiefs | ESPN |
| 5 | Sunday, Oct. 7, 2018 – 11:00 AM MST | @ New York Jets | CBS |
| 6 | Sunday, Oct. 14, 2018 – 2:05 PM MST | Los Angeles Rams | FOX |
| 7 | Thursday, Oct. 18, 2018 – 6:20 PM MST | @ Arizona Cardinals | FOX |
| 8 | Sunday, Oct. 28, 2018 -11:00 AM MST | @ Kansas City Chiefs | CBS |
| 9 | Sunday, Nov. 4, 2018 – 2:05 PM MST | Houston Texans | CBS |
| 10 | BYE WEEK | BYE | BYE |
| 11 | Sunday, Nov. 18, 2018 – 2:05 PM MST | @ Los Angeles Chargers | CBS |
| 12 | Sunday, Nov. 25, 2018 – 2:25 PM MST | Pittsburgh Steelers | CBS |
| 13 | Sunday, Dec. 2, 2018 – 11:00 AM MST | @ Cincinnati Bengals | CBS |
| 14 | Sunday, Dec. 9, 2018 – 2:05 PM MST | @ San Francisco 49ers | CBS |
| 15 | Saturday, Dec. 15, 2018 – TBD | Cleveland Browns | NFLN |
| 16 | Monday, Dec. 24, 2018 – 6:15 PM MST | @ Oakland Raiders | ESPN |
| 17 | Sunday, Dec. 30, 2018 – 2:25 PM MST | Los Angeles Chargers | CBS |
